Published fork

Abnormal expression of ATP1A1 and ATP1A2 in breast cancer

Fork of pmid:28529692 · Abnormal expression of ATP1A1 and ATP1A2 in breast cancer · by Automated Assays Administrator · published to the Journal on 3 Nov 2026, 15:46

What this page is

This is a fork of a published paper. The definition was written on this platform, the run was made here on real data, and the version was then published to the Journal. The comparison below is between that run and the values the paper printed.

It is a repeatable re-analysis of the deposited data with this platform’s own group comparison. It is not a reproduction of the paper’s pipeline: the steps of that pipeline are listed below with the ones this platform does not run, and nothing here claims otherwise.

The paper

Title: Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
Journal: F1000Research 2017
DOI: 10.12688/f1000research.10481.1
PMID: 28529692
Corpus record: pmid:28529692
Corpus revision: Revision 6 (1.5)
Corpus content hash: sha256:116bf117cc3112c78abf15a5c35878e88e5fab508f979460005284568439dbe5
Corpus tier: R4 · blocked on method:microarray_rma_normalise

The claim the corpus published

ATP1A1 was overexpressed approximately 1.5 times in all groups of breast cancer samples (p<0.05). Coincidently, ATP1A2 expression decreased by more than 2 times (p<0.05).

The experiment definition

The version published to the Journal, as the platform held it when it published.

Revision: 8
Content hash: sha256:26c4153596d79a37288fac302e042eedf392341ff41d031a6c3fdb56881fa565
Document hash: 62c035118c952860077d66c38eceeb1562b45a23938f9247842db2f8a2f0d827
Forks from: pmid:28529692
Parent version hash: sha256:ba5107d1ce6eda8cb1bc4309689cbade3a4eef170b65343d9166cb012e7aaae6
Generation: 7
Reason recorded: Saved the launch-gate run made against the published fork version.

Assays in this version

group-comparison-analysis

· ordered by platform_plan_order:0

Download the published .sci file

The runs

Every run this platform made against the fork, with the comparison it reached with the paper and the hashes that let the run be checked.

group_comparison_anova 0.1.0

complete partly reproduced made against revision 5

54,673 features tested across 141 samples in 5 groups; 22,426 differential.

Cohort

This run counted 141 experimental units in the paper's 5 groups (30 Her2, 41 TNBC, 11 Healthy, 29 Luminal A, 30 Luminal B), which is the same group count as the paper states. This is an agreement of counts: the paper publishes no sample identifiers, so it is not an identity of specimens, and the paper does not say how it handled its own technical replicates. The repository holds 178 arrays; 46 of them carry the repository's own replicate marker, and averaging them removed 23 arrays and left the experimental units this run counted. CellLine 14 is outside the paper's cohort.

— The paper publishes no sample identifiers, so what is compared here is the number of experimental units in each group and not the identity of each specimen.
— The paper does not publish how it handled its own technical replicates, so the rule that produced these units is the repository's structure as the platform read it and not the paper's own rule.
— The experimental units are the repository's arrays averaged after the depositor's own replicate marker was removed.

Claims checked against the paper

ATP1A1 partly reproduced 4 contrasts · 0 reproduced · 0 direction only · 3 partly · 1 contradicted

Luminal A against Healthy partly reproduced

244606_at contradicted paper 1.53 , p 0.009016 run 0.967619 , p 2.38e-6 36.8% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.53 , p 0.009016 run 1.477288 , p 0.002553 3.4% from the published value , tolerance 25.0%

Luminal B against Healthy contradicted

244606_at contradicted paper 1.38 , p 0.04454 run 0.973736 , p 2.38e-6 29.4% from the published value , tolerance 25.0%

220948_s_at significance only paper 1.38 , p 0.04454 run 1.365716 , p 0.002553 1.0% from the published value , tolerance 25.0%

Her2 against Healthy partly reproduced

244606_at contradicted paper 1.66 , p 0.005926 run 0.977794 , p 2.38e-6 41.1% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.66 , p 0.005926 run 1.708049 , p 0.002553 2.9% from the published value , tolerance 25.0%

TNBC against Healthy partly reproduced

244606_at contradicted paper 1.44 , p 0.015725 run 0.976144 , p 2.38e-6 32.2% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.44 , p 0.015725 run 1.621305 , p 0.002553 12.6% from the published value , tolerance 25.0%

Luminal A: the observed change is not an increase; the run goes the other way (published ratio 1.5300, run ratio 0.9676); Luminal B: the observed change is not an increase; the run goes the other way (published ratio 1.3800, run ratio 0.9737); the run agrees with the published ratio 1.3800 but reaches a significance the paper did not (published p 0.044540, run p 0.096332 against the same two groups); Her2: the observed change is not an increase; the run goes the other way (published ratio 1.6600, run ratio 0.9778); TNBC: the observed change is not an increase; the run goes the other way (published ratio 1.4400, run ratio 0.9761)
ATP1A2 direction only 4 contrasts · 0 reproduced · 4 direction only · 0 partly · 0 contradicted

Luminal A against Healthy direction only

203296_s_at direction only paper 0.401606 , p 1.85e-7 run 0.036208 , p 1.22e-37 91.0% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.401606 , p 1.85e-7 run 0.224409 , p 3.09e-16 44.1% from the published value , tolerance 25.0%

Luminal B against Healthy direction only

203296_s_at direction only paper 0.396825 , p 8.5e-9 run 0.028244 , p 1.22e-37 92.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.396825 , p 8.5e-9 run 0.222551 , p 3.09e-16 43.9% from the published value , tolerance 25.0%

Her2 against Healthy direction only

203296_s_at direction only paper 0.359712 , p 5.48e-8 run 0.029065 , p 1.22e-37 91.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.359712 , p 5.48e-8 run 0.225171 , p 3.09e-16 37.4% from the published value , tolerance 25.0%

TNBC against Healthy direction only

203296_s_at direction only paper 0.348432 , p 2.08e-11 run 0.031254 , p 1.22e-37 91.0% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.348432 , p 2.08e-11 run 0.233499 , p 3.09e-16 33.0% from the published value , tolerance 25.0%

Luminal A: the run gets the direction right but its ratio 0.0362 is 91.0% from the published ratio 0.4016, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2244 is 44.1% from the published ratio 0.4016, outside the declared tolerance of 25%; Luminal B: the run gets the direction right but its ratio 0.0282 is 92.9% from the published ratio 0.3968, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2226 is 43.9% from the published ratio 0.3968, outside the declared tolerance of 25%; Her2: the run gets the direction right but its ratio 0.0291 is 91.9% from the published ratio 0.3597, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2252 is 37.4% from the published ratio 0.3597, outside the declared tolerance of 25%; TNBC: the run gets the direction right but its ratio 0.0313 is 91.0% from the published ratio 0.3484, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2335 is 33.0% from the published ratio 0.3484, outside the declared tolerance of 25%
ATP1A3 reproduced 4 contrasts · 4 reproduced · 0 direction only · 0 partly · 0 contradicted

Luminal A against Healthy reproduced

214432_at reproduced paper 0.952381 , p 0.429089 run 0.987372 , p 0.002985 3.7% from the published value , tolerance 25.0%

Luminal B against Healthy reproduced

214432_at reproduced paper 1.03 , p 0.308298 run 0.991701 , p 0.002985 3.7% from the published value , tolerance 25.0%

Her2 against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.768041 run 0.995745 , p 0.002985 3.6% from the published value , tolerance 25.0%

TNBC against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.527878 run 0.994019 , p 0.002985 3.4% from the published value , tolerance 25.0%

The paper’s method, step by step

Microarray preprocessing Expression Console 1.4 Not implemented here

Operations this platform does not have: microarray_rma_normalise
One-way analysis of variance Transcriptome Analysis Console 3.0 Implemented here
Group comparison against a reference group Not implemented here

Operations this platform does not have: group_relative_expression

The run in full The evidence manifest

group_comparison_anova 0.1.0

complete partly reproduced made against revision 2 superseded record

54,673 features tested across 164 samples in 5 groups; 22,628 differential.

This run was recorded before the platform compared a run against the cohort the paper states, so its sample-set comparison is a superseded record and not a current claim about the paper. The counts above are the ones it recorded.

Claims checked against the paper

ATP1A1 partly reproduced 4 contrasts · 0 reproduced · 0 direction only · 3 partly · 1 contradicted

Luminal A against Healthy partly reproduced

244606_at contradicted paper 1.53 , p 0.009016 run 0.967619 , p 1.9e-6 36.8% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.53 , p 0.009016 run 1.477288 , p 0.002024 3.4% from the published value , tolerance 25.0%

Luminal B against Healthy contradicted

244606_at contradicted paper 1.38 , p 0.04454 run 0.973736 , p 1.9e-6 29.4% from the published value , tolerance 25.0%

220948_s_at significance only paper 1.38 , p 0.04454 run 1.365716 , p 0.002024 1.0% from the published value , tolerance 25.0%

Her2 against Healthy partly reproduced

244606_at contradicted paper 1.66 , p 0.005926 run 0.977778 , p 1.9e-6 41.1% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.66 , p 0.005926 run 1.708785 , p 0.002024 2.9% from the published value , tolerance 25.0%

TNBC against Healthy partly reproduced

244606_at contradicted paper 1.44 , p 0.015725 run 0.975762 , p 1.9e-6 32.2% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.44 , p 0.015725 run 1.607839 , p 0.002024 11.7% from the published value , tolerance 25.0%

Luminal A: the observed change is not an increase; the run goes the other way (published ratio 1.5300, run ratio 0.9676); Luminal B: the observed change is not an increase; the run goes the other way (published ratio 1.3800, run ratio 0.9737); the run agrees with the published ratio 1.3800 but reaches a significance the paper did not (published p 0.044540, run p 0.096332 against the same two groups); Her2: the observed change is not an increase; the run goes the other way (published ratio 1.6600, run ratio 0.9778); TNBC: the observed change is not an increase; the run goes the other way (published ratio 1.4400, run ratio 0.9758)
ATP1A2 direction only 4 contrasts · 0 reproduced · 4 direction only · 0 partly · 0 contradicted

Luminal A against Healthy direction only

203296_s_at direction only paper 0.401606 , p 1.85e-7 run 0.036208 , p 1.71e-44 91.0% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.401606 , p 1.85e-7 run 0.224409 , p 3.02e-19 44.1% from the published value , tolerance 25.0%

Luminal B against Healthy direction only

203296_s_at direction only paper 0.396825 , p 8.5e-9 run 0.028244 , p 1.71e-44 92.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.396825 , p 8.5e-9 run 0.222551 , p 3.02e-19 43.9% from the published value , tolerance 25.0%

Her2 against Healthy direction only

203296_s_at direction only paper 0.359712 , p 5.48e-8 run 0.029026 , p 1.71e-44 91.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.359712 , p 5.48e-8 run 0.224655 , p 3.02e-19 37.5% from the published value , tolerance 25.0%

TNBC against Healthy direction only

203296_s_at direction only paper 0.348432 , p 2.08e-11 run 0.030499 , p 1.71e-44 91.2% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.348432 , p 2.08e-11 run 0.230763 , p 3.02e-19 33.8% from the published value , tolerance 25.0%

Luminal A: the run gets the direction right but its ratio 0.0362 is 91.0% from the published ratio 0.4016, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2244 is 44.1% from the published ratio 0.4016, outside the declared tolerance of 25%; Luminal B: the run gets the direction right but its ratio 0.0282 is 92.9% from the published ratio 0.3968, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2226 is 43.9% from the published ratio 0.3968, outside the declared tolerance of 25%; Her2: the run gets the direction right but its ratio 0.0290 is 91.9% from the published ratio 0.3597, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2247 is 37.5% from the published ratio 0.3597, outside the declared tolerance of 25%; TNBC: the run gets the direction right but its ratio 0.0305 is 91.2% from the published ratio 0.3484, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2308 is 33.8% from the published ratio 0.3484, outside the declared tolerance of 25%
ATP1A3 reproduced 4 contrasts · 4 reproduced · 0 direction only · 0 partly · 0 contradicted

Luminal A against Healthy reproduced

214432_at reproduced paper 0.952381 , p 0.429089 run 0.987372 , p 0.004335 3.7% from the published value , tolerance 25.0%

Luminal B against Healthy reproduced

214432_at reproduced paper 1.03 , p 0.308298 run 0.991701 , p 0.004335 3.7% from the published value , tolerance 25.0%

Her2 against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.768041 run 0.995987 , p 0.004335 3.6% from the published value , tolerance 25.0%

TNBC against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.527878 run 0.99376 , p 0.004335 3.4% from the published value , tolerance 25.0%

The run in full The evidence manifest

group_comparison_anova 0.1.0

complete partly reproduced made against revision 4

54,673 features tested across 141 samples in 5 groups; 22,426 differential.

Cohort

— The paper publishes no sample identifiers, so what is compared here is the number of experimental units in each group and not the identity of each specimen.
— The experimental units are the repository's arrays averaged after the depositor's own replicate marker was removed. The paper does not publish how it handled its own replicates, so this is the repository's structure as the platform read it.

Claims checked against the paper

ATP1A1 partly reproduced 4 contrasts · 0 reproduced · 0 direction only · 3 partly · 1 contradicted

Luminal A against Healthy partly reproduced

244606_at contradicted paper 1.53 , p 0.009016 run 0.967619 , p 2.38e-6 36.8% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.53 , p 0.009016 run 1.477288 , p 0.002553 3.4% from the published value , tolerance 25.0%

Luminal B against Healthy contradicted

244606_at contradicted paper 1.38 , p 0.04454 run 0.973736 , p 2.38e-6 29.4% from the published value , tolerance 25.0%

220948_s_at significance only paper 1.38 , p 0.04454 run 1.365716 , p 0.002553 1.0% from the published value , tolerance 25.0%

Her2 against Healthy partly reproduced

244606_at contradicted paper 1.66 , p 0.005926 run 0.977794 , p 2.38e-6 41.1% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.66 , p 0.005926 run 1.708049 , p 0.002553 2.9% from the published value , tolerance 25.0%

TNBC against Healthy partly reproduced

244606_at contradicted paper 1.44 , p 0.015725 run 0.976144 , p 2.38e-6 32.2% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.44 , p 0.015725 run 1.621305 , p 0.002553 12.6% from the published value , tolerance 25.0%

Luminal A: the observed change is not an increase; the run goes the other way (published ratio 1.5300, run ratio 0.9676); Luminal B: the observed change is not an increase; the run goes the other way (published ratio 1.3800, run ratio 0.9737); the run agrees with the published ratio 1.3800 but reaches a significance the paper did not (published p 0.044540, run p 0.096332 against the same two groups); Her2: the observed change is not an increase; the run goes the other way (published ratio 1.6600, run ratio 0.9778); TNBC: the observed change is not an increase; the run goes the other way (published ratio 1.4400, run ratio 0.9761)
ATP1A2 direction only 4 contrasts · 0 reproduced · 4 direction only · 0 partly · 0 contradicted

Luminal A against Healthy direction only

203296_s_at direction only paper 0.401606 , p 1.85e-7 run 0.036208 , p 1.22e-37 91.0% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.401606 , p 1.85e-7 run 0.224409 , p 3.09e-16 44.1% from the published value , tolerance 25.0%

Luminal B against Healthy direction only

203296_s_at direction only paper 0.396825 , p 8.5e-9 run 0.028244 , p 1.22e-37 92.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.396825 , p 8.5e-9 run 0.222551 , p 3.09e-16 43.9% from the published value , tolerance 25.0%

Her2 against Healthy direction only

203296_s_at direction only paper 0.359712 , p 5.48e-8 run 0.029065 , p 1.22e-37 91.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.359712 , p 5.48e-8 run 0.225171 , p 3.09e-16 37.4% from the published value , tolerance 25.0%

TNBC against Healthy direction only

203296_s_at direction only paper 0.348432 , p 2.08e-11 run 0.031254 , p 1.22e-37 91.0% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.348432 , p 2.08e-11 run 0.233499 , p 3.09e-16 33.0% from the published value , tolerance 25.0%

Luminal A: the run gets the direction right but its ratio 0.0362 is 91.0% from the published ratio 0.4016, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2244 is 44.1% from the published ratio 0.4016, outside the declared tolerance of 25%; Luminal B: the run gets the direction right but its ratio 0.0282 is 92.9% from the published ratio 0.3968, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2226 is 43.9% from the published ratio 0.3968, outside the declared tolerance of 25%; Her2: the run gets the direction right but its ratio 0.0291 is 91.9% from the published ratio 0.3597, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2252 is 37.4% from the published ratio 0.3597, outside the declared tolerance of 25%; TNBC: the run gets the direction right but its ratio 0.0313 is 91.0% from the published ratio 0.3484, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2335 is 33.0% from the published ratio 0.3484, outside the declared tolerance of 25%
ATP1A3 reproduced 4 contrasts · 4 reproduced · 0 direction only · 0 partly · 0 contradicted

Luminal A against Healthy reproduced

214432_at reproduced paper 0.952381 , p 0.429089 run 0.987372 , p 0.002985 3.7% from the published value , tolerance 25.0%

Luminal B against Healthy reproduced

214432_at reproduced paper 1.03 , p 0.308298 run 0.991701 , p 0.002985 3.7% from the published value , tolerance 25.0%

Her2 against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.768041 run 0.995745 , p 0.002985 3.6% from the published value , tolerance 25.0%

TNBC against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.527878 run 0.994019 , p 0.002985 3.4% from the published value , tolerance 25.0%

The paper’s method, step by step

Microarray preprocessing Expression Console 1.4 Not implemented here

Operations this platform does not have: microarray_rma_normalise
One-way analysis of variance Transcriptome Analysis Console 3.0 Implemented here
Group comparison against a reference group Not implemented here

Operations this platform does not have: group_relative_expression

The run in full The evidence manifest

group_comparison_anova 0.1.0

complete partly reproduced recorded in the published version

54,673 features tested across 141 samples in 5 groups; 22,426 differential.

Cohort

— The paper publishes no sample identifiers, so what is compared here is the number of experimental units in each group and not the identity of each specimen.
— The paper does not publish how it handled its own technical replicates, so the rule that produced these units is the repository's structure as the platform read it and not the paper's own rule.
— The experimental units are the repository's arrays averaged after the depositor's own replicate marker was removed.

Claims checked against the paper

ATP1A1 partly reproduced 4 contrasts · 0 reproduced · 0 direction only · 3 partly · 1 contradicted

Luminal A against Healthy partly reproduced

244606_at contradicted paper 1.53 , p 0.009016 run 0.967619 , p 2.38e-6 36.8% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.53 , p 0.009016 run 1.477288 , p 0.002553 3.4% from the published value , tolerance 25.0%

Luminal B against Healthy contradicted

244606_at contradicted paper 1.38 , p 0.04454 run 0.973736 , p 2.38e-6 29.4% from the published value , tolerance 25.0%

220948_s_at significance only paper 1.38 , p 0.04454 run 1.365716 , p 0.002553 1.0% from the published value , tolerance 25.0%

Her2 against Healthy partly reproduced

244606_at contradicted paper 1.66 , p 0.005926 run 0.977794 , p 2.38e-6 41.1% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.66 , p 0.005926 run 1.708049 , p 0.002553 2.9% from the published value , tolerance 25.0%

TNBC against Healthy partly reproduced

244606_at contradicted paper 1.44 , p 0.015725 run 0.976144 , p 2.38e-6 32.2% from the published value , tolerance 25.0%

220948_s_at reproduced paper 1.44 , p 0.015725 run 1.621305 , p 0.002553 12.6% from the published value , tolerance 25.0%

Luminal A: the observed change is not an increase; the run goes the other way (published ratio 1.5300, run ratio 0.9676); Luminal B: the observed change is not an increase; the run goes the other way (published ratio 1.3800, run ratio 0.9737); the run agrees with the published ratio 1.3800 but reaches a significance the paper did not (published p 0.044540, run p 0.096332 against the same two groups); Her2: the observed change is not an increase; the run goes the other way (published ratio 1.6600, run ratio 0.9778); TNBC: the observed change is not an increase; the run goes the other way (published ratio 1.4400, run ratio 0.9761)
ATP1A2 direction only 4 contrasts · 0 reproduced · 4 direction only · 0 partly · 0 contradicted

Luminal A against Healthy direction only

203296_s_at direction only paper 0.401606 , p 1.85e-7 run 0.036208 , p 1.22e-37 91.0% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.401606 , p 1.85e-7 run 0.224409 , p 3.09e-16 44.1% from the published value , tolerance 25.0%

Luminal B against Healthy direction only

203296_s_at direction only paper 0.396825 , p 8.5e-9 run 0.028244 , p 1.22e-37 92.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.396825 , p 8.5e-9 run 0.222551 , p 3.09e-16 43.9% from the published value , tolerance 25.0%

Her2 against Healthy direction only

203296_s_at direction only paper 0.359712 , p 5.48e-8 run 0.029065 , p 1.22e-37 91.9% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.359712 , p 5.48e-8 run 0.225171 , p 3.09e-16 37.4% from the published value , tolerance 25.0%

TNBC against Healthy direction only

203296_s_at direction only paper 0.348432 , p 2.08e-11 run 0.031254 , p 1.22e-37 91.0% from the published value , tolerance 25.0%

203295_s_at direction only paper 0.348432 , p 2.08e-11 run 0.233499 , p 3.09e-16 33.0% from the published value , tolerance 25.0%

Luminal A: the run gets the direction right but its ratio 0.0362 is 91.0% from the published ratio 0.4016, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2244 is 44.1% from the published ratio 0.4016, outside the declared tolerance of 25%; Luminal B: the run gets the direction right but its ratio 0.0282 is 92.9% from the published ratio 0.3968, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2226 is 43.9% from the published ratio 0.3968, outside the declared tolerance of 25%; Her2: the run gets the direction right but its ratio 0.0291 is 91.9% from the published ratio 0.3597, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2252 is 37.4% from the published ratio 0.3597, outside the declared tolerance of 25%; TNBC: the run gets the direction right but its ratio 0.0313 is 91.0% from the published ratio 0.3484, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2335 is 33.0% from the published ratio 0.3484, outside the declared tolerance of 25%
ATP1A3 reproduced 4 contrasts · 4 reproduced · 0 direction only · 0 partly · 0 contradicted

Luminal A against Healthy reproduced

214432_at reproduced paper 0.952381 , p 0.429089 run 0.987372 , p 0.002985 3.7% from the published value , tolerance 25.0%

Luminal B against Healthy reproduced

214432_at reproduced paper 1.03 , p 0.308298 run 0.991701 , p 0.002985 3.7% from the published value , tolerance 25.0%

Her2 against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.768041 run 0.995745 , p 0.002985 3.6% from the published value , tolerance 25.0%

TNBC against Healthy reproduced

214432_at reproduced paper 0.961538 , p 0.527878 run 0.994019 , p 0.002985 3.4% from the published value , tolerance 25.0%

The paper’s method, step by step

Microarray preprocessing Expression Console 1.4 Not implemented here

Operations this platform does not have: microarray_rma_normalise
One-way analysis of variance Transcriptome Analysis Console 3.0 Implemented here
Group comparison against a reference group Not implemented here

Operations this platform does not have: group_relative_expression

The run in full The evidence manifest

The published fork

Journal state: published
Published: 3 Nov 2026, 15:46
Version: Revision 8
Content hash: sha256:26c4153596d79a37288fac302e042eedf392341ff41d031a6c3fdb56881fa565
Journal record: fork:pmid:28529692:abnormal-expression-of-atp1a1-and-atp1a2-in-breast-cancer-30ee8f18

Hashes of the first run

Dataset hash: f92d2109fe0d64ed056d9673e8733b2af25173230f3632e370201b6a4054caba
Result hash: 9dd46f386a0e57d0d15cb2c6ecea5f48be988ebee6bdb03185e9373809493ac6
Evidence bundle (canonical hash): 7d6e68368f4e57c5bf3fc7c047891d14bed7a479b42bcbc59828dea0b10faf95
Source version hash: sha256:c3c73dd6f35221cb129768c5ed0585965cb6621ead665dccb8a975ea3b87c829

What was not reproduced

— The paper's step "Microarray preprocessing" is not implemented on this platform (missing: microarray_rma_normalise).
— The paper's step "Group comparison against a reference group" is not implemented on this platform (missing: group_relative_expression).
— The paper states no multiplicity procedure, so the corrections this platform applies across pairs (Holm) and across features (Benjamini-Hochberg) are the platform's own and are not a reproduction of a correction the paper made.
— The paper's own pipeline needs software the platform does not run: Expression Console 1.4 software and Transcriptome Analysis Console 3.0 software (Affymetrix, Inc. USA) are available after free customer registration at: http://www.affymetrix.com/support/technical/software_downloads.affx. The route is published with the record, and the condition it carries is part of the route.
— The paper's step "Microarray preprocessing" is not implemented on this platform (missing: microarray_rma_normalise).
— The paper's step "Group comparison against a reference group" is not implemented on this platform (missing: group_relative_expression).
— The paper states no multiplicity procedure, so the corrections this platform applies across pairs (Holm) and across features (Benjamini-Hochberg) are the platform's own and are not a reproduction of a correction the paper made.
— The paper's step "Microarray preprocessing" is not implemented on this platform (missing: microarray_rma_normalise).
— The paper's step "Group comparison against a reference group" is not implemented on this platform (missing: group_relative_expression).
— The paper states no multiplicity procedure, so the corrections this platform applies across pairs (Holm) and across features (Benjamini-Hochberg) are the platform's own and are not a reproduction of a correction the paper made.
— The paper's own pipeline needs software the platform does not run: Expression Console 1.4 software and Transcriptome Analysis Console 3.0 software (Affymetrix, Inc. USA) are available after free customer registration at: http://www.affymetrix.com/support/technical/software_downloads.affx. The route is published with the record, and the condition it carries is part of the route.