Automated Assays Automated Assays

Published fork

Abnormal expression of ATP1A1 and ATP1A2 in breast cancer

Fork of pmid:28529692 · Check pmid:28529692 figures · by Automated Assays Administrator · published to the Journal on 2 Nov 2026, 04:29

What this page is

This is a fork of a published paper. The definition was written on this platform, the run was made here on real data, and the version was then published to the Journal. The comparison below is between that run and the values the paper printed.

It is a repeatable re-analysis of the deposited data with this platform’s own group comparison. It is not a reproduction of the paper’s pipeline: the steps of that pipeline are listed below with the ones this platform does not run, and nothing here claims otherwise.

The paper

Title
Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
Journal
F1000Research 2017
DOI
10.12688/f1000research.10481.1
PMID
28529692
Corpus record
pmid:28529692
Corpus revision
Revision 6 (1.5)
Corpus content hash
sha256:116bf117cc3112c78abf15a5c35878e88e5fab508f979460005284568439dbe5
Corpus tier
R4 · blocked on method:microarray_rma_normalise

The claim the corpus published

ATP1A1 was overexpressed approximately 1.5 times in all groups of breast cancer samples (p<0.05). Coincidently, ATP1A2 expression decreased by more than 2 times (p<0.05).

The experiment definition

The version published to the Journal, as the platform held it when it published.

Revision
8
Content hash
sha256:6803696d12a8098d47823d250008744b159fdf353fac02c84671a77b46f26234
Document hash
020f5f7ca612b05f78dcb54abeaedbf6818d29a7f410c9703dc986df887f4746
Forks from
pmid:28529692
Parent version hash
sha256:597ab1b2b4d3af05deac209ed6b3bef79d7ad5fa1eabc8484a99c7b5ecd63c1d
Generation
4
Reason recorded
Updated from the experiment state.

Assays in this version

  • group-comparison-analysis

    · ordered by platform_plan_order:0

Download the published .sci file

The runs

Every run this platform made against the fork, with the comparison it reached with the paper and the hashes that let the run be checked.

group_comparison_anova 0.1.0

complete partly reproduced recorded in the published version superseded record

54,673 features tested across 164 samples in 6 groups; 22,628 differential.

This run was recorded before the platform compared a run against the cohort the paper states, so its sample-set comparison is a superseded record and not a current claim about the paper. The counts above are the ones it recorded.

Claims checked against the paper

  • ATP1A1 partly reproduced 4 contrasts · 0 reproduced · 0 direction only · 3 partly · 1 contradicted
    Luminal A against Healthy partly reproduced
    244606_at contradicted paper 1.53 , p 0.009016 run 0.967619 , p 1.9e-6 36.8% from the published value , tolerance 25.0%
    220948_s_at reproduced paper 1.53 , p 0.009016 run 1.477288 , p 0.002024 3.4% from the published value , tolerance 25.0%
    Luminal B against Healthy contradicted
    244606_at contradicted paper 1.38 , p 0.04454 run 0.973736 , p 1.9e-6 29.4% from the published value , tolerance 25.0%
    220948_s_at significance only paper 1.38 , p 0.04454 run 1.365716 , p 0.002024 1.0% from the published value , tolerance 25.0%
    Her2 against Healthy partly reproduced
    244606_at contradicted paper 1.66 , p 0.005926 run 0.977778 , p 1.9e-6 41.1% from the published value , tolerance 25.0%
    220948_s_at reproduced paper 1.66 , p 0.005926 run 1.708785 , p 0.002024 2.9% from the published value , tolerance 25.0%
    TNBC against Healthy partly reproduced
    244606_at contradicted paper 1.44 , p 0.015725 run 0.975762 , p 1.9e-6 32.2% from the published value , tolerance 25.0%
    220948_s_at reproduced paper 1.44 , p 0.015725 run 1.607839 , p 0.002024 11.7% from the published value , tolerance 25.0%

    Luminal A: the observed change is not an increase; the run goes the other way (published ratio 1.5300, run ratio 0.9676); Luminal B: the observed change is not an increase; the run goes the other way (published ratio 1.3800, run ratio 0.9737); the run agrees with the published ratio 1.3800 but reaches a significance the paper did not (published p 0.044540, run p 0.096332 against the same two groups); Her2: the observed change is not an increase; the run goes the other way (published ratio 1.6600, run ratio 0.9778); TNBC: the observed change is not an increase; the run goes the other way (published ratio 1.4400, run ratio 0.9758)

  • ATP1A2 direction only 4 contrasts · 0 reproduced · 4 direction only · 0 partly · 0 contradicted
    Luminal A against Healthy direction only
    203296_s_at direction only paper 0.401606 , p 1.85e-7 run 0.036208 , p 1.71e-44 91.0% from the published value , tolerance 25.0%
    203295_s_at direction only paper 0.401606 , p 1.85e-7 run 0.224409 , p 3.02e-19 44.1% from the published value , tolerance 25.0%
    Luminal B against Healthy direction only
    203296_s_at direction only paper 0.396825 , p 8.5e-9 run 0.028244 , p 1.71e-44 92.9% from the published value , tolerance 25.0%
    203295_s_at direction only paper 0.396825 , p 8.5e-9 run 0.222551 , p 3.02e-19 43.9% from the published value , tolerance 25.0%
    Her2 against Healthy direction only
    203296_s_at direction only paper 0.359712 , p 5.48e-8 run 0.029026 , p 1.71e-44 91.9% from the published value , tolerance 25.0%
    203295_s_at direction only paper 0.359712 , p 5.48e-8 run 0.224655 , p 3.02e-19 37.5% from the published value , tolerance 25.0%
    TNBC against Healthy direction only
    203296_s_at direction only paper 0.348432 , p 2.08e-11 run 0.030499 , p 1.71e-44 91.2% from the published value , tolerance 25.0%
    203295_s_at direction only paper 0.348432 , p 2.08e-11 run 0.230763 , p 3.02e-19 33.8% from the published value , tolerance 25.0%

    Luminal A: the run gets the direction right but its ratio 0.0362 is 91.0% from the published ratio 0.4016, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2244 is 44.1% from the published ratio 0.4016, outside the declared tolerance of 25%; Luminal B: the run gets the direction right but its ratio 0.0282 is 92.9% from the published ratio 0.3968, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2226 is 43.9% from the published ratio 0.3968, outside the declared tolerance of 25%; Her2: the run gets the direction right but its ratio 0.0290 is 91.9% from the published ratio 0.3597, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2247 is 37.5% from the published ratio 0.3597, outside the declared tolerance of 25%; TNBC: the run gets the direction right but its ratio 0.0305 is 91.2% from the published ratio 0.3484, outside the declared tolerance of 25%; the run gets the direction right but its ratio 0.2308 is 33.8% from the published ratio 0.3484, outside the declared tolerance of 25%

  • ATP1A3 reproduced 4 contrasts · 4 reproduced · 0 direction only · 0 partly · 0 contradicted
    Luminal A against Healthy reproduced
    214432_at reproduced paper 0.952381 , p 0.429089 run 0.987372 , p 0.004335 3.7% from the published value , tolerance 25.0%
    Luminal B against Healthy reproduced
    214432_at reproduced paper 1.03 , p 0.308298 run 0.991701 , p 0.004335 3.7% from the published value , tolerance 25.0%
    Her2 against Healthy reproduced
    214432_at reproduced paper 0.961538 , p 0.768041 run 0.995987 , p 0.004335 3.6% from the published value , tolerance 25.0%
    TNBC against Healthy reproduced
    214432_at reproduced paper 0.961538 , p 0.527878 run 0.99376 , p 0.004335 3.4% from the published value , tolerance 25.0%
The run in full The evidence manifest